MRSA Patients Need to Clean House
19th March 2007 by Arrow Durfee Posted in Uncategorized
1: Dent Mater J. 2002 Mar;21(1):53-60.
Effect of denture cleaner using ozone against methicillin-resistant Staphylococcus aureus and E. coli T1 phage.
-1. Murakami H, Mizuguchi M, Hattori M, Ito Y, Kawai T, Hasegawa J.
Department of Fixed Prosthodontics, Division of Biomaterials, Research Institute of Advanced Oral Science, School of Dentistry, Aichi-Gakuin University, 2-11 Suemori-dori, Chikusa-ku, Nagoya, Japan, 464-8651.
We examined the bactericidal and virucidal effectiveness of a denture cleaner that uses ozone (ozone concentration, 10 ppm) against methicillin-resistant Staphylococcus aureus (MRSA) and T1 phage, respectively. In the bactericidal activity test, with the ozone supply turned on, the number of bacteria was 3.1 x 10(3) CFU/mL at the beginning of the experiment, fell to 1.0 x 10(0) CFU/mL 10 min later, and was 1.0 x 10(0) CFU/mL or less afterwards. In contrast, when the ozone supply was cut off (air bubble only), the number of bacteria was 3.4 x 10(3) CFU/mL at the beginning of the experiment, and had fallen to 3.0 x 10(3) CFU/mL 60 min later (no statistically significant difference). In the virucidal activity test, the number of phages was 1.2 x 10(6) PFU/mL before ozone treatment, fell to about 1/10 of that number 10 min later, and was 6.1 x 10(0) PFU/mL 40 min later. These results indicate that the use of ozone in this denture cleaner is effective against MRSA and viruses.
PMID: 12046522 [PubMed - indexed for MEDLINE]
: Drugs Exp Clin Res. 1993;19(2):59-64.
Microbicidal effects of ozone solution on methicillin-resistant Staphylococcus aureus.
-1. Yamayoshi T, Tatsumi N.
Department of Environmental Microbiology, Osaka Prefectural Institute of Public Health, Japan.
Methicillin-resistant Staphylococcus aureus has become an important problem in chemotherapy in the past decade because of its resistance to commonly used disinfectants. The usefulness of ozone solutions to disinfect against strains of this bacterium has been evaluated. Ozone strongly oxidizes the cell walls and cytoplasmic membranes of bacteria. The microbicidal effect of ozone solutions took place within the first five seconds of treatment. An ozone concentration 1.5 times that needed to kill the one methicillin-sensitive strain tested was sufficient to kill the resistant clinical isolates. Such an ozone solution could be used to disinfect medical instruments and similar equipment. Ozone solutions should be useful in reducing the number of bacterial infections caused by inadequate disinfection against new resistant strains.
PMID: 8223143 [PubMed - indexed for MEDLINE]