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Cancer, Ozone and Autohemotherapy

17th April 2007 by Arrow Durfee Posted in Uncategorized

Link to Dr Contreras’ Clinic, Check out the chart on this page: www.oasisofhope.com/clinical_results.html

Autohemotherapy: An effective tool to fight cancer
By. Francisco Contreras, MD.

When most people hear the word ozone, they think of a protective layer of our atmosphere but aren’t really sure what it is beyond that. Ozone is oxygen but with the molecular structure O 3 instead of O 2 . This additional molecule makes ozone a highly reactive oxidant. If inhaled, ozone can do some serious damage to our bodies. However, there is an application of this substance that is very therapeutic. But first, let’s take a closer look at ozone.

In nature, ozone has a good side and a bad side. In the stratosphere, it acts as a shield, deflecting harmful UV irradiation. However, in the troposphere, ozone is a major component of the smog that harms humans, animals, and plants. When we breathe it, ozone can cause serious pulmonary and systemic side effects because it is such a powerful oxidant. a*

It has been shown that ozone possesses broad-spectrum antimicrobial activity. b*
This means that it fights the bacteria that cause infection. In the First World War, it was used by medics to save the lives of wounded soldiers suffering from gaseous gangrene. Today ozonated solutions and ozonated oils are still used to treat wounds and a host of infections. Ozone therapies are used to treat fistulae, abscesses, ulcers, gingivitis, stomatitis, and osteomyelitis. In addition, ozone has been widely used in sewage treatment and water purification processes because it is such an effective bacterial scavenger. c*

On the world scene, ozone therapy became an alternative medical approach in 1954, when Wehrly and Steinbart first described its application. They found that while the human respiratory tract reacts very negatively to ozone, human blood does not. In fact, when exposed to appropriate ozone concentrations, our blood tames the strong oxidant properties of ozone, thus eliminating any acute side effects. The benefits derived from this therapy are staggering.

Oasis doctors know that ozonation of the blood improves the exchange of oxygen in the blood, activates the immune system, and increases the efficiency of the antioxidant system. What is most exciting to us is how these three things combine to effectively retard or reverse tumor growth. It is obvious to our doctors that ozone is useful in the treatment of degenerative diseases like cancer.

Over the last seven years, doctors at Oasis have advanced the use of ozone therapy, the results have been extraordinary. Our patients have experienced measurable tumor reduction quickly, sometimes in as little as two weeks. For long-term results, we still believe that metabolic therapy is vital, but it is wonderful to get fast results, too. Let me explain how ozone therapy is administered.

Autohemotherapy is the process of bringing small quantities of blood into contact with ozone.d* This ozone therapy is performed each year on several hundred thousand patients around the world, mostly in Russia, Poland, Greece, Germany, Switzerland, Italy, Austria, Belgium and Cuba.e* The medical ozone used in this therapy is an O 2 /O 3 mixture with a low ozone concentration. The ozone generators used to produce this mixture are incredibly precise.f*

Autohemotherapy is typically performed in one of two ways. The standard technique is to withdraw 150-250 ml of blood and expose it to a O 2 /O 3 mixture at a specified ozone concentration, followed by intravenous reinfusion of this blood into the patient. g*At the Oasis of Hope, we have the option of running an extracorporeal loop to ozonate all of the patient’s blood. This second technique involves automatically running the blood through a continuous recirculating device which mixes ozone and blood in a closed loop before reinfusing it. h*

The results from two very recent studies proved the safety and effectiveness of the ozonation of blood in humans. No significant changes in blood chemistry or other parameters were found. The patients felt no particular sensations during treatment. The treatment session was followed by a feeling of well-being and euphoria, lasting several hours. Most importantly, there was a total lack of side effects. The authors conclude that blood ozonation is clinically valid, without side effects and that there are at least four areas , namely infectious diseases, vascular disorders, degenerative diseases (particularly metastatic cancer), and pathologies related to immune depression, where this treatment could be useful when orthodox therapies have failed .i* All of these factors fall within the principles embraced by Oasis doctors.

So, how does the ozone actually work? Personally, I am fascinated by the cascade of effects ozone provokes when it is introduced into the bloodstream. Ozone decomposes in blood and interacts immediately with several substances, namely fatty acids, cholesterols, proteins, and carbohydrates. j* When the ozone decomposes a series of reactive oxygen species are quickly produced, the most important of which is hydrogen peroxide (H 2 O 2 ).

A sudden rise in H 2 O 2 concentration triggers very different biochemical activity depending upon the type of cell the H 2 O 2 penetrates. k* If the H 2 O 2 penetrates red cells and endothelial cells, three things happen. First, there is an increase in the delivery and release of oxygen by red cells toward the tissues.l* Then, in areas of the system that were constricted, endothelial cells enhance release of nitric oxide (NO) m* resulting in dilation of blood vessels and improving oxygen flow.n*Finally, the formation of new blood vessels (angiogenesis) is inhibited due to the improvement of oxygenation in the neoplastic tissue. Remember, tumors feed on blood vessels. Thus, anything that reduces the formation of blood vessels helps to restrain tumor growth.

When H 2 O 2 penetrates cells known as leukocytes, it induces the production of specialized biological assassins called cytokines. These include interleukins, interferon, and tumor necrosis factor. o*The cytokines launch an array of immune functions, such as macrophages and neutrophils, which slow tumor growth and metastasis.p*

The presence of H 2 O 2 in the blood increases the efficiency with which the body eliminates oxidants. We know that persistent oxidative stress from free radicals, or oxidants, is at the root of degenerative diseases like cancer. Countless findings show that aging, chronic viral infections, cancer, autoimmune diseases, and neurodegenerative diseases are all accompanied by a reduction in the body’s ability to detoxify itself properly.

Without question, ozone therapy will rapidly become an essential tool for oncologists and an integral part of comprehensive treatment programs. Over the next few years, Oasis doctors will continue to refine the use of ozone therapy. I expect even more dramatic results.

a*
Pryor WA, Squadrito GL, Friedman M. The cascade mechanisms to explain ozone toxicity: The role of lipid ozonation products. Free Rad Biol Med 1995,19:935-941.
Bocci V. Does ozone therapy normalize the cellular redox balance?: Implications for the therapy of human immunodeficiency virus infection and several other diseases. Medical Hypotheses 1996,46:150-154

b* Wells KH, Latino J, Gavalchin J, and Poiesz B. Inactivation of human immunodeificiency virus type 1 by ozone in vitro. Blood 1991,78:1882-1890.

c* Bocci V. Does ozone therapy normalize the cellular redox balance?: Implications for the therapy of human immunodeficiency virus infection and several other diseases. Medical Hypotheses 1996,46:150-154.

d* Bocci V. Ozonization of blood for the therapy of viral disease and immunodeficiencies. A hypothesis. Medical Hypotheses 1992,39:30-34.

e* Bocci V. Is ozone therapy therapeutic? Perspectives in Biology and Medicine 1998,42:131-143.

f*
Wells KH, Latino J, Gavalchin J, and Poiesz B. Inactivation of human immunodeificiency virus type 1 by ozone in vitro. Blood 1991,78:1882-1890.
Carpendale TF, and Freeberg JK. Ozone inactivates HIV at noncytotoxic concentrations. Antiviral Res 1991,16:281-292.

g*
Bocci V. Does ozone therapy normalize the cellular redox balance?: Implications for the therapy of human immunodeficiency virus infection and several other diseases. Medical Hypotheses 1996,46:150-154.
Hernández F, Menéndez S, and Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiophathy patients treated with endovenous ozone therapy. Free Rad Biol Med 1995,19(1):115-119.

h* Di Paolo N, Bocci V, Garosi G, Borrelli E, Bravi A, Bruci A, Aldinucci C, and Capotondo L. Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. Int J Artif Organs 2000,23(2):131-141.

i*
Coppola L, Verrazzo G, Giunta R et al. Oxygen/ozone therapy and haemorheological parameters in peripheral chronic arterial occlusive disease. Throm. Arterioscler. 1992,8:83-90.
Tylicki L, Nieweglowski T, Biedunkiewicz B, Burakowski S, and Ruthowski B. Beneficial clinical effects of ozonated autohemotherapy in chronically dialysed patients with atherosclerotic ischemia of the lower limbs-pilot study. Int J Artif Organs 2001, 24:79-82.
Hernández F, Menéndez S, and Wong R. Decrease of blood cholesterol and stimulation of antioxidative response in cardiophathy patients treated with endovenous ozone therapy. Free Rad Biol Med 1995,19(1):115-119.
Di Paolo N, Bocci V, Garosi G, Borrelli E, Bravi A, Bruci A, Aldinucci C, and Capotondo L. Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. Int J Artif Organs 2000,23(2):131-141.

j*
Pryor WA, Squadrito GL, Friedman M. The cascade mechanisms to explain ozone toxicity: The role of lipid ozonation products. Free Rad Biol Med 1995,19:935-941.
Pryor WA. Mechanisms of radical formation from reactions of ozone with target molecules in the lung. Free Rad Biol Med 1994, 17:451-465.

k* Bocci V. Is ozone therapy therapeutic? Perspectives in Biology and Medicine 1998,42:131-143.

l*
Bocci V. Is ozone therapy therapeutic? Perspectives in Biology and Medicine 1998,42:131-143.
Di Paolo N, Bocci V, Garosi G, Borrelli E, Bravi A, Bruci A, Aldinucci C, and Capotondo L. Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. Int J Artif Organs 2000,23(2):131-141.
Bocci V, Valacchi G, Corradeschi F, Aldinucci C, Silvestri S, Paccagnini A, and Gerli R. Studies on the biological effects of ozone; 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. J Biol Reg Homeost Agents 1998, 12(3):67-75.

m* Nitric oxide: A gas molecule that is critical to numerous biological processes, including vasodilaton, neurotransmission and tumor-killing.

n*
Bocci V. Is ozone therapy therapeutic? Perspectives in Biology and Medicine 1998,42:131-143.
Bocci V, Luzzi E, Corradeshi F, Paulesu L, and Di Stefano A. Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines. Lymphokine and Cytokine Research 1993, 12 (2):121-126.
Bocci V, Valacchi G, Corradeschi F, and Fanetti G. Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production. Mediators of Inflammation 1998, 7:313-317.
Bocci V, and Paulesu L. Studies on the biological effects of ozone: 1. Induction of interferon gamma on human leucocytes. Haematologica 1990, 75:510-515.
Paulesu L, Luzzi E, and Bocci V. Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor (TNF) on human leucocytes. Lymphokyne and Cytokine Research 1991, 10:409-412.
Valacchi and Bocci V. Studies on the biological effects of ozone: 11. Releasing factors from human endothelial cells. Mediators of Inflammation 2000, 9 (6): 271-276.

o* Bocci V. Ozonization of blood for the therapy of viral disease and immunodeficiencies. A hypothesis. Medical Hypotheses 1992,39:30-34.

p*
Toyokuni S, Okamoto K, Yodoi J, and Hiai H. Persistent oxidative stress in cancer. FEBS Letters 1995, 358: 1-3.
Ames BN, Shigenaga MK, and Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Nat Acad Sci USA 1993, 90:7915-7922.
Schwarz KB. Oxidative stress during viral infection: A review. Free Rad Biol Med 1996, 21:641-649.
Simonian NA, and Coyle JT. Oxidative stress in neurodegenerative diseases. Ann. Rev. Pharmacol. Toxicol. 1996, 36:83-106.

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