Health Salon

30TH ANNUAL MEETING OF EUROPEAN THYROID ASSOCIATION
Istanbul, Turkey, 18-22 September 2004
P.111 (Abstract No: 257)
IS IODINE PROPHYLAXIS (IP) A PROTECTIVE FACTOR AGAINST GASTRIC CANCER IN IODINE DEFICIENT AREAS?
(1)Szybinski Z, (2)Rachtan J , (1)Huszno B , (1)Hubalewska A , (1)Buziak-Bereza M , (1)Trofimiuk M , (1)Collegium Medicum, Jagiellonian University Chair and Department of Endocrinology Krakow Poland,(2)Oncologic Center M.Sklodowska-Curie s Institute of Oncology Krakow Poland
Epidemiological data reveal an association between gastric cancer incidence rate (GCIR) and iodine deficiency (ID) in endemic goiter areas. The “Venturi hypothesis” is based on the correlation between ID and high GC mortality rate due to common derivation of thyroid gland and stomach from primitive gut. Gastric mucosa and thyroid folliculi can accumulate iodine, have similar enzymes involved in iodine metabolism, are able to iodise tyrosine and express
similar cross-reacting antigens.
The aims of the study were:
1. to compare iodine nutrition after introduction of obligatory IP in 1997 and GCIR
2. to evaluate GCIR in years 1985-1999.

METHODS:
GCIR in Kraków region was calculated using standardized population based register with 100% of histological verification and 85-90% of ascertainment. GCIR was expressed as a number of newly diagnosed cases per 100.000 inhabitants per year. Effectiveness of IP was evaluated by comparative analysis of goiter prevalence and ioduria in schoolchildren carried out in epidemiological survey performed in 1992/1993 and in 1994-2003.

RESULTS Iodine supply on the population level was expressed as a number of tons of iodized household salt on the market: 4000 tones in 1994 and 120.000 tones in 2003. Goiter prevalence in 6-8 years old schoolchildren decreased from 34% in 1992/93 g/L increased from 12% in(to 2,7% in 2003 and frequency of ioduria over 100 1992/1993 to 33-55% in 1999-2003. According to WHO and ICCIDD, Poland is now the country with sufficient iodine supply on the population level. GCIR decreased from 24,2 (92 cases) in 1985-1987 to 17,9 in 1997-1999, all cancers crude incidence rate increased markedly from 273,3 to 380,1 respectively.

CONCLUSIONS:
1. Significant positive correlation between iodine nutrition on the population level and decrease of
GCIR seems to support “Venturi hypothesis” in Poland.
2. Presented data indicate the protective role of IP against gastric cancer.

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