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Cetyl Myristoleate for Arthritis, CMO, Rheumatoid Arthritis, Osteoarthritis

9th December 2007 by Arrow Durfee Posted in Uncategorized

CMO may be your best chance to cure the inflammatory processes of RA and osteoarthritis. Dr. Donsbach uses CMO to help lead to his overwhelming success in treating severe arthritis patients in his clinic in Mexico. Some people do not have success in treating their arthritis with alternative compounds because the inflammation is so severe. CMO will remove the inflammation, usually in one to two months. When the inflammation is gone products like glucosamine will work better at reconstructing cartilage. Older people may also require a growth hormone precursor.

In my personal case the crippling inflammation was gone in one week of CMO use. I have only had to use it a handful of times over the last 16 years. I have found Serrapeptase helpful when CMO did not work. Usually it works for me.

Be sure to read the first part of the article on this Arthritis thread called the Ultimate Solution to Heart Disease,Stroke and Alzheimers. You need to learn about Microlantin.

 The inflameze product that I mention in the comments that follow this article are no longer available. I recommend these instead:

My first choice is this product because it is developed by Dr Donsbach as the Inflameze was. Unlike Inflameze it has a number of herbs in it. This site also offers a CMO topical cream that I have not tried but may be helpful:  www.letstalkhealth.com/Liposomal-RE-LEV-IT-p/629.htm

These products are pure CMO. I have not personally used them as I am still working on my stash of Inflameze.  I would go with the Jarrow or NOW FOODS Brand.www.iherb.com/search?kw=cmo%2C%20cetyl%20myristoleate

Cetyl Myristoleate: A Unique Natural Compound, Valuable in Arthritis Conditions

A Sponsored Article

by Dr. Charles Cochran and Dr. Raymond Dent

Introduction

Arthritis is a disease of epidemic proportions, but it has been around for so many centuries that it is considered by most people as a part of growing old or a consequence of physical injury. Arthritis is in fact a far more complex disease than is generally known. For instance, Dorland’s Medical Dictionary describes 27 different types of arthritis, and that does not include such diverse conditions as systemic lupus erythematosus, scleroderma, fibromyalgia, and numerous other conditions which some authorities consider to be types of arthritis.1 One authority states that there are approximately 100 causes for arthritis.2

Arthritis is thought to affect more than 50 million Americans, and is generally accepted to be the leading cause of movement limitation and disability. It deserves and receives a great deal of research and medical attention. There are hundreds of drugs, procedures, and medical aids and devices directed at coping with the many manifestations of the disease. Given this degree of complexity, certainly no one agent alone could ever be expected to manage or cure “arthritis” in its entirety. New agents take their place in the spectrum and make a contribution. Now there is a relatively new discovery of a natural substance, cetyl myristoleate, which shows promise of making a great contribution in non-infective types of arthritis.

Cetyl Myristoleate

Cetyl myristoleate was discovered and isolated by one person, working alone, on a quest to find a cure for arthritis. Harry W. Diehl, while employed by the National Institute of Arthritis, Metabolism, and Digestive Diseases, specialized in sugar chemistry. He used his chemical knowledge and research instincts to great advantage, identifying and characterizing over 500 compounds, several of which were patented by the National Institutes of Health (NIH). His most significant discovery before cetyl myristoleate was a method of synthesizing 2-deoxydextroribose, a sugar used in the preparation of oral polio vaccine by Dr. Jonas Salk.3

Diehl’s interest in discovering a way to help victims of arthritis began over 40 years ago when his friend and next door neighbor, a carpenter, developed severe rheumatoid arthritis. His condition deteriorated over time until he became disabled. The neighbor had a family to support, but his arthritis made that impossible. Diehl is a deeply religious man whose feelings overwhelmed him as his friend’s condition worsened. Harry thought, “Here I am working at the National Institutes of Health, and I have never seen anything that was good for curing arthritis.”4 He decided to establish a laboratory in his home and embark on a search for something to relieve the pain and disability of his neighbor and the millions of people who suffer from arthritis. Unfortunately, he was too late to help the neighbor, but Diehl’s research did lead to the discovery of cetyl myristoleate, which may someday be hailed as one of the significant nutritional discoveries of the 20th century.

The Quest

As a researcher, Diehl knew that finding a cure for arthritis first meant inducing the disease experimentally in research animals. He started with mice, and quickly realized that he was unable to induce arthritis in them. Diehl said he tried every way he could to give those mice arthritis, but they just would not get it. Then, he contacted a researcher in California who wrote to him, “If you or anyone else can give mice arthritis, I want to know about it, because mice are 100% immune to arthritis.”5 At that moment, Diehl’s research instincts told him that what he wanted was already somewhere in those mice.

It was a long, tedious job, working on his own in his spare time, but Diehl finally found the factor – cetyl myristoleate – that protected mice from arthritis. As Diehl said, “It didn’t come on a silver platter to me, but after years of chemical sleuthing and just old-fashioned chemical cooking, I found it!” On thin layer chromatography of methylene chloride extract from macerated mice, Diehl noticed a mysterious compound, which was subsequently identified as cetyl myristoleate. As Diehl was to prove, cetyl myristoleate circulates in the blood of mice and makes them immune to arthritis.

Cetyl myristoleate is now known to exist in sperm whale oil and in a small gland in the male beaver. At this time no other sources in nature are known to contain cetyl myristoleate. While the first amounts of cetyl myristoleate for experimentation were extracted from mice, Diehl quickly developed a method for making cetyl myristoleate in the lab by the esterification of myristoleic acid.

Chemistry

Cetyl myristoleate, an oil, is the hexadecyl ester of the unsaturated fatty acid cis-9-tetradecenoic acid. The common name for the acid is myristoleic acid. Myristoleic acid is found commonly in fish oils, whale oils, dairy butter, and kombo butter. The chemical formula for cetyl myristoleate is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3. Cetyl myristoleate was unrecorded in chemical literature until Diehl’s discovery was reported. The current Merck Index of Chemicals does not list cetyl myristoleate. A search of Chemical Abstracts lists Diehl’s method of extracting cetyl myristoleate from mice but contains no reference to cetyl myristoleate prior to his 1977 patent.

Experimentation

To test his theory that mice are immune to arthritis because of cetyl myristoleate, Diehl began to experiment on laboratory rats. This research was reported in an article written in conjunction with one of his colleagues at NIH in the Journal of Pharmaceutical Sciences.6 In summary, this paper reports that ten normal mice were injected in the tail with Freund’s Adjuvant (heat-killed desiccated Mycobacterium butyricum) to which rats and certain other rodents are susceptible. In a period of 10-20 days, no noticeable swelling developed in the legs or paws. Mice in a second group were injected in the left hind paw. Again, after 10-20 days, no swelling was detected as determined by comparison of the measurements of paws at the time of injection.

Then, a group of rats was injected with cetyl myristoleate, and 48 hours later, they were given the arthritis-inducing Freund’s adjuvant. A control group of rats was given Freund’s adjuvant only. Both groups of rats were observed for a total of 58 days with respect to weight change, hind and front leg swelling, and general well-being. All rats receiving only Freund’s adjuvant developed severe swelling of the front and hind legs, lagged in weight gain, and were lethargic and morbid. Those receiving cetyl myristoleate before receiving Freund’s adjuvant grew an average of 5.7 times as much as the control group and had little if any evidence of swelling or other symptoms of polyarthritis.

The authors concluded that it was apparent that cetyl myristoleate gave virtually complete protection against adjuvant-induced arthritis in rats. Furthermore, a 1:1 mixture of cetyl myristoleate and a homologue, cetyl oleate, gave results not significantly different from administering cetyl myristoleate alone.

A Hiatus

Diehl patented his discovery in 1977, receiving a use patent for rheumatoid arthritis. He then sought pharmaceutical companies to conduct human trials with cetyl myristoleate, but none were interested in his discovery. Perhaps the lack of interest was because cetyl myristoleate was a natural substance and could not be granted a product patent, or maybe because drug companies know they will have to run through 25,000 to 35,000 substances before they find one that makes it to market. Diehl had made a major nutritional discovery, and no one was interested! Being a scientist, not a marketing expert, Diehl let his discovery lay dormant for about 15 years.

Cetyl Myristoleate Cures

Diehl’s Arthritis

As Diehl got older, he began to experience some osteoarthritis in his hands, his knees, and his heels. His family physician tried the usual regimen of cortisone and non-steroidal anti-inflammatory drugs without much effect on the course of the disease. Finally his physician told Harry he could not have any more cortisone. “So,” Diehl said, “I thought about my discovery, and I decided to make a batch and use it on myself.” He did, and successfully cured himself of his osteoarthritis.

Many of his family members and friends became aware of the relief Diehl got from his discovery, and they wanted to try it too. Time after time, people with both rheumatoid and osteoarthritis received astounding relief with cetyl myristoleate. Before long, family members and friends grew into customers, and cetyl myristoleate appeared on the market as a dietary supplement in 1991.

Clinical Observations and Usage

In common with many other natural substances and drugs, the exact mechanism of cetyl myristoleate’s physiologic activity is unclear. As a fatty acid ester, it appears to have the same characteristics as the essential fatty acids, linoleic and alpha linolenic acids, except stronger and longer lasting. These fatty acids are referred to as “essential fatty acids” because the human body cannot make them and we must ingest them in our diets. These EFA’s truly are essential to normal cell structure and body function and function as components of nerve cells, cell membranes, and hormone-like substances known as prostaglandins. Many of the beneficial effects of a diet rich in plant foods is a result of the low levels of saturated fat and the relatively higher levels of EFA’s. While a diet high in saturated fat has been linked to many chronic diseases, a diet low in saturated fat but high in EFA’s prevents these very same diseases.7 The use of EFA’s over an extended period of time has been shown to decrease the pain, inflammation, and limitation of motion of arthritis.8

The difference between the activity of EFA’s and cetyl myristoleate is that the quantity required and the period of time over which EFA’s are taken are markedly longer. Cetyl myristoleate is taken in a one month course of about 13 grams, while EFA’s must be taken over extended periods, sometimes many years, and intake varies widely from hundreds to thousands of grams. Cetyl myristoleate seems to have properties in common with EFA’s, but it acts faster and lasts longer.

Because EFA’s are necessary for normal functioning of all tissue, it is not surprising that the list of symptoms of EFA deficiency is a long one. In chronic inflammatory processes, the supply of EFA’s is depleted. Cetyl myristoleate appears to have the ability to correct the imbalance created by chronic inflammation. Like EFA’s, maybe cetyl myristoleate turns off the fires of chronic inflammation by serving as a mediator of prostaglandin formation and metabolism.

Venous blood from the gastrointestinal tract is carried to the liver via the portal vein. With the exception of intestinal chylomicrons that enter the lymphatics, all absorbed products pass initially through the liver, and in most instances are extracted or modified before passage into systemic circulation.9 Since all fatty acids enter systemic circulation through the liver, an oil like cetyl myristoleate would begin its systemic circulation from the liver also. It is speculated that cetyl myristoleate stimulates the production of immunoglobulins and series 1 and 3 prostaglandins, which could be one explanation for why cetyl myristoleate has such potent effect in auto-immune and inflammatory conditions.

Cases

Here are some cases involving the use of cetyl myristoleate from the author’s practice.

Leona – She is a 64 year old mother of five who has been developing degenerative changes in her fingers over the last 15 years. She plays the piano frequently and had to reduce the amount of playing time as a result of the arthritis pain in her fingers. ANA titers have been mildly elevated over the years and rheumatoid disease has been diagnosed in several of her ancestors and one sibling. Leona’s other medical problems are mild hypertension and chronic sacro-lumbar pain which appears to be attributable both to sciatic damage sustained in a water skiing accident 24 years ago and Shunerman’s disease as teenager. Demonstrating both rheumatoid and osteoarthritis changes in her fingers, she has a mild nodular deformity at the terminal joints of the 3rd and 4th fingers on the left hand and fusiform swelling in the medial and distal joints of most of her fingers. Her thumbs were intermittently painful and swollen. She first took cetyl myristoleate in mid-January, 1997. There is now increased range of motion in all of the finger joints and visible reduction of the rheumatoid-like swelling. The nodular deformities have not changed noticeably. Her back problems demonstrated no improvement. Her sedimentation rate has run from 15 to 35, and is currently 16, with her ANA <1:360. Leona is now able to play the piano all she wants to without pain or swelling of her fingers.

Joyce - She is a 42 year old mother of three and a court reporter in good general health, suffering only from moderate hayfever in the spring. Recently Joyce developed a generalized stiffness and soreness in her fingers, which was worse on her right hand. The condition became so bad over a couple of weeks that she began making numerous mistakes in her court reporting and her speed was significantly reduced. She was diagnosed with tenosynovitis. Joyce shows no deformities of her hands associated with arthritis. She began a course of cetyl myristoleate during the last week of February and finished the last week of March, 1997. She reports complete restoration of her dexterity with return of her normal accuracy and speed, along with elimination of the associated pain.

Bob - He is a 67 year-old retired politician who suffered lumbar and pelvic fractures in WWII when his jeep struck a land mine. Over the years, these injuries produced increasing pain, which seriously affected routine daily activities like getting out of bed in the morning and his ability to play golf. X-rays demonstrate degenerative arthritic changes in the lumbar articulations and the right sacroiliac joint. At 6 feet tall and 185 pounds, he is otherwise in good health. Bob has been using anti-inflammatory drugs for over 20 years, including Voltaren, ibuprofen, Tylenol, and aspirin. He took a one-half course of 7.6 grams of cetyl myristoleate in September, 1996. He experienced moderately severe inflammation (breakthrough pain) on day two which lasted for three days. On the 4th day, the pain began to subside and was completely gone by the 5th day. He has been virtually pain-free since and is very happy with the increased comfort with which he can begin each day. He can now comfortably walk the golf course whereas before he was limited to a golf cart. In February, 1997, he perceived a slight return of his low back pain and decided to take another one-half course. He experienced no breakthrough pain this time and is currently pain-free. He has not taken any other medication for his back pain since taking cetyl myristoleate initially.

Virginia - She is an 85 year-old lady who still works part-time at the family-owned business and cares for her husband who has cancer. Virginia was diagnosed ten years ago with diabetes, and elevated triglycerides and cholesterol. Overweight all her life, she is now stable at 265 pounds. She suffers from long-standing osteoarthritis in her knees and ankles, for which she was placed on cetyl myristoleate. No other agents have been used by her for arthritis except for non-steroidal anti-inflammatory drugs, both OTC and prescription. After about 7.6 grams of cetyl myristoleate, she was able to walk without limping or experiencing significant pain. About three months following the initial course, some pain returned, but she has retained what she estimates to be 50% improvement. She also has gallstones and a recurrent problem with gout, both of which have been symptomless since her cetyl myristoleate course. She evidently did not receive enough cetyl myristoleate for her body weight and will be given another course of 13.25 grams.

Rose - Rose is a 46 year old mother of four who works as a legal secretary. She was diagnosed five years ago as having an atypical form of multiple sclerosis. She had MRI exams of the skull and spinal cord, which demonstrated several areas of non-specific degenerative changes in the brain with several "bright spots" in the cervical spinal cord. She had periodic visual aberrations as well as constant fatigue and fibromyalgia-like pains focused in her trapezius (bilaterally), and in her upper arms and legs below the knees. She also complained of burning sensations in her hands and feet. All of the symptoms worsened with elevated stress. There was no sign of pernicious anemia or diabetes. She was receiving chiropractic therapy. Joyce was started on numerous naturopathic therapies in March, 1996 without significant benefit over an eight month period. In November, 1996, she started on cetyl myristoleate and indicated that she felt more fatigued for the first three days but that the pain in her upper back and extremities was completely gone. She further reported that the tingling/burning sensation in her feet and hands was also gone. Rose felt this was the most striking aspect of the treatment as those areas were the ones most constantly affected. This improvement lasted until she had to travel out of state to tend to her mother who was diagnosed with a rapidly advancing malignancy. Over the next three weeks, her symptoms began to reappear. After the death of her mother, she returned home in as bad shape as before first taking cetyl myristoleate. She decided that she wanted to take another half course of cetyl myristoleate, which completely duplicated the relief from the initial dosage with the exception that she feels slightly less relief from her tendencies to fatigue than she did after the first course. Rose will be taking another half course to see if she can improve her stamina.

J.P. - He is a 60 year old male who has been a farmer his entire life. Diagnosed with rheumatoid arthritis 15 years ago, he has been on various pharmacologic protocols during that time. The most recent includes Plaquenil, methotrexate, and prednisone, with daily non-steroidal anti-inflammatory drug dosing. J.P. has fusiform swelling involving most of the joints of his fingers and moderate ulnar deviation of both hands. He suffered severe pain most of the time which limited the labor he could perform. He began cetyl myristoleate during the last week of February, 1997, at which time he terminated his methotrexate and Plaquenil (not recommended except in consultation with a qualified physician). He has also reduced his prednisone from 15 milligrams per day to 5 mg, but he still maintains his NSAID dosing on a daily basis. J.P. experienced a mild increase in pain during the first four days of taking cetyl myristoleate, but since then he has been pain free and the swelling in his hands is reducing. J.P. will be monitored over the next month to determine his stability, with checking of his serum parameters by an MD. If he continues to remain symptom-free, his steroid and NSAID therapies will be terminated. J.P. does not smoke, eat chocolate, nor drink alcohol or caffeinated beverages. He was advised at the onset of his cetyl myristoleate dosage to avoid sugar. He is also taking Glucosaplex (a mix of glucosamines) and Lyprinol (fatty acid extract of green lipped mussel) as an additional natural anti-inflammatory agent.

Optimizing the Effects of Cetyl Myristoleate

Since the days of Paracelsus, physicians have been combining therapeutic agents for synergistic effects, or to achieve potentiation of several compounds. As powerful a nutrient as it is, the effects of cetyl myristoleate can be helped by combining it with other natural substances. Two or three grams daily of omega-3 fish oil or two tablespoonfulls of flaxseed oil during the month-long course of cetyl myristoleate can help its effects. This should be accompanied by 300-500 mg of Vitamin E daily. A minimum of 1,500 mg of glucosamine sulfate should be taken daily for at least three months to assist in rebuilding cartilage damaged by degenerative arthritis. In severe cases, three to six grams of glucosamine daily for one month and reduced to 1,500 mg daily for three months has been found to be very effective. Afterwards, a daily maintenance of 500 mg of glucosamine should be used for healthy cartilage. If stomach upset occurs, glucosamine should be taken with meals.

Clinical experience has shown that glucosamine sulfate is far superior when compared to cartilage extracts, such as sea cucumber, hydrolyzed bovine cartilage, and shark cartilage. This is due to the increased absorption and utilization of glucosamine sulfate compared to these sources of chrondroitin sulfates, which are very large molecules and difficult to digest. Animal and human studies have shown up to 98% absorption of glucosamine,10,11 compared to only 8% absorption of chrondroitin sulfate.12

One of the reasons that glucosamine sulfate is more effective in rebuilding cartilage when compared to other sources of glucosamine, including the N-acetyl and hydrochloride forms, is that it provides bioavailable dietary sulfur. Sulfur helps provide the protein links necessary for cartilage matrix repair. Another source of sulfur is methylsulfonylmethane (MSM), which has been used historically to treat a wide variety of conditions including allergies, emphysema, arthritis, gastrointestinal upset, and some vascular conditions. MSM is a metabolite of dimethylsulfoxide (DMSO) and provides many similar good effects. MSM is found in most natural unprocessed foods. Because of its volatility, MSM is lost when fresh food is cooked, processed, or stored. The richest source of MSM is mother's milk; consequently, very few nursing infants are deficient in dietary sulfur.

As with any oil, cetyl myristoleate requires lipase to be digested. Lipases are pancreatic enzymes that play a key role in the digestion of fats and fat soluble vitamins. If lipase is absent or deficient, cetyl myristoleate will be poorly absorbed, if at all. As many arthritis patients are of the age when lipase production decreases, approximately 100 mg of lipase enzyme should be taken with each cetyl myristoleate capsule. In addition to taking lipase, cholecystectomy patients will need lecithin or ox bile extract to assure absorption.

Diet can play a role in optimizing the benefits of cetyl myristoleate. Carbonated cola beverages and citrus juices may block the absorption of cetyl myristoleate and should be avoided on the days cetyl myristoleate is taken. Sugar intake should be minimized when taking cetyl myristoleate, and adding refined sugar to liquids like coffee and tea should be avoided altogether. Alcohol and caffeine intake should be very limited or eliminated altogether while combating arthritis and chronic inflammatory conditions.

Reported Results

Both osteoarthritis and rheumatoid arthritis sufferers report striking improvement with cetyl myristoleate. Numerous private correspondence describes decreased stiffness and pain, and increased flexibility and range of motion with cetyl myristoleate. Swelling and redness is reduced in rheumatoid arthritis. Writers describe other health benefits, including positive effect of cetyl myristoleate on emphysema, hepatitis, hypertension, diabetes, eczema, psoriasis, colds, allergies, low back pain, and headaches. These reported improvements in general health status are not surprising since each of these conditions could be associated with deficiency in the balance of EFA's.

Like everything else, cetyl myristoleate does not work 100% of the time. Failure to work can be associated with failure to follow the dietary recommendations; failure to use lipase in conjunction with each capsule of cetyl myristoleate; failure to take a sufficient amount of cetyl myristoleate; failure of the liver to uptake and respond to the cetyl myristoleate; and, misdiagnosis in which the condition is not really an arthritis-type condition.

Dosage

Cetyl myristoleate is taken in a one month course. A total dose of 12 to 15 grams appears to be indicated. This is usually enough for most people, but for osteoarthritis sufferers, the dose appears to be related to the number of sites in which cartilage has worn away. For example, a patient with osteoarthritis of the knees could expect 10 to 15 grams to be sufficient in most cases, while a patient with osteoarthritis of 5 or 6 spinal discs, both hips, and both knees may require an additional 5 to 10 grams, or even a full second course. Some of the patients treated by the author would likely have benefited even more from their cetyl myristoleate usage with the larger doses now recommended.

Contraindications and Toxicity

With the tens of thousands of people who have taken cetyl myristoleate there have been no confirmed reports of adverse side effects. In common with fish oils, it may produce some mild burping in some people which passes within an hour. There have been no reported interactions with other medications or natural substances, and other substances (except those mentioned above as diet considerations) do not interfere with cetyl myristoleate.

While teratogenicity of cetyl myristoleate is probably the same as for EFA's, as a safety matter cetyl myristoleate should not be used by pregnant or lactating women until studies of cetyl myristoleate's effects on fetuses and infants have been done. As with any substance being added to the diet of anyone with asthma or a history of severe allergic reactions, caution is advised and cetyl myristoleate should be used in these cases under the direct supervision of a health care professional.

Toxicity studies have been performed on cetyl myristoleate and the lack of toxicity is evident. Test results deemed cetyl myristoleate a non-toxic material in accordance with Federal regulations. Mega-doses were given to test animals with no ill effects. Necropsy of test animals showed no ill effects on their internal organs.13 The LD50 of cetyl myristoleate was not established, but it can be presumed to far exceed 10 grams per kilogram of body weight.

Correspondence:

Dr. Charles L. Cochran
226 Lake Court
Aptos, California 95003 USA

Dr. Raymond Dent
RR 1, Box 169
Lymington Road
Limmerick, Maine 04048 USA

References

1. Dorland's Medical Dictionary, 25th Ed.

2. Shils, Olson, and Shike. Modern Nutrition in Health and Disease. Lea & Febigen, 1994. Philadelphia, PA. p. 1480

3. Diehl, H. W. and Fletcher, H. G., A Simplified Preparation of 2-Deoxy-D-ribose Based on Treatment of a-D- Glucose Monohydrate with Solid Calcium Hydroxide, Archives of Biochemistry and Biophysics, Vol. 78, No. 2, Dec. 1958

4. Wright, M.D., J., and Gaby, M.D., A, Nutrition and Healing, August, 1996, Vol.3, Issue 8, paraphrase from page 5.

5. Private correspondence to H. W. Diehl, Rockville, Md. from Dr. Fay Wood, Univ. of Cal., Berkeley, 1969

6. Diehl, H. W. and May, E. L., Cetyl Myristoleate Isolated from Swiss Albino Mice: An Apparent Protective Agent against Adjuvant Arthritis in Rats. Jour. of Pharmaceutical Sciences, Vol. 83, No. 3, Mar, 94 pp296-299.

7. Murray, M. T. Encyclopedia of Nutritional Supplements, Prima Publishing, Rocklin, CA 1996 p. 237

8. Sobel, D. and Klein, A. C.. Arthritis: What Works. St. Martins Press, New York, NY. pp. 221-225

9. Shils, Olson, and Shike. Ibid. pg. 550.

10. Setnikar, I., et al., Pharmacokinetics of glucosamine in man. Arztneim Forsch 43 (10), 1109-1113, 1993

11. Setnikar, I., et al., Pharmacokinetics of glucosamine in the dog and man. Arztneim Forsch 36(4), 729-735, 1986.

12. Morrison, M., Therapeutic applications of chrondroitin-4-sulfate, appraisal of biologic properties. Folia Angiol 25, 225-232, 1977.

13. Leberco Testing, Inc., Jan. 22, 1996, private correspondence to EHP Products, Inc.

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12 Responses to “Cetyl Myristoleate for Arthritis, CMO, Rheumatoid Arthritis, Osteoarthritis”

  1. Arrow Durfee Says:

    If your relative has had a knee x-rays and there I absolutely no cartilage left between the bones the chances of these things helping are slim. But even if there is a little cartilage left it may be helpful.

    Inflameze CMO capsules is the product you want to try. It is an anti-inflammatory, natural medicine that will help to take the inflammation out of the joints. One bottle is for one month. If there is not any improvement after 2 weeks double the dosage. You may need to purchase 2 or 3 bottles for severe cases.*****about $15 each.

    Purchase it n the internet at http://www.reachforlife.com or

    Phone in USA: 1-800- 421-7310
    International phone: 001-918-437-7310

    >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

    Glucosamine will help to rebuild cartilage between the joint bones. Start this after you have been taking Inflameze for one week. Do not walk much but rest for the first week of taking Inflameze. Do gentle range of motion exercises. Here is a good brand of glusosamine because it has MSM with it. When you start the glucosamine you need to start walking again. No more than one week off your feet.….. You will need to be on this product for a long time. You may need to repeat the CMO occasionally.

    Doctors Best Brand – Synergistic Glusosamine MSM Formula.
    180 capsules. You will need 4 caps 2 times a day for the first couple of months. So one bottle will last 25 days. Its $12 per bottle. All orders over $40 are shipped free of charge.
    Purchase glucosamine at iherb company phone: 1-800-972-0028

    >>>>>>>>>>>>>>>>>>>>>>>>>>>>>

    There is one more product that may be very helpful but it is expensive so I mention it last as the other products may do the trick alone. It is called hyaluronic acid and again, Doctors Best Hyaluronic Acid with Condrointin may be worth a try. I would double the dosage for the first few weeks. Order at http://www.iherb.com also.

    There is another product called DMSO that is very helpful for pain and it is rubbed on the joints. It is a linament. You can get it at 1-800-367-6935

  2. Arrow Durfee Says:

    http://www.glucosamine-arthritis.org/arthritis/cetyl-myristoleate-arthritis.html

    Science or Speculation
    By painfree56@lycos.com

    There are a lot of fabulous stories about Cetyl Myristoleate (also known as CMO or CM) floating across the Internet. Mine is one of them. There have been a number of articles published in little known journals or magazines. There have been four small booklets published. One making fantastic claims, all four filled with anecdotal evidence but offering no real research to back up the claims. There are a number of doctors sharing the results they are having with their patients, but so does every other wonder-working product. The question is, are there any scientific studies to back up any of these claims? The answer is yes. To date, there are several patient studies and two double blind studies completed. I will mention the four most prominent below.

    Dr. Len Sands of the San Diego Clinic completed the first human study on the effectiveness on Cetyl Myristoleate in 1995. There were 48 arthritis patients in this study. All but two showed significant improvement in articular mobility (80% or better) and reduction of pain (70% or better). Obviously the study had its flaws. One doctor conducted the study, there was no control group, and the number of participants was small. Even so, it suggested to many that maybe there was some hope here and that more scientific studies should follow.

    The first double blind study followed two years later. Dr. H. Siemandi conducted a double blind study under the auspices of the Joint European Hospital Studies Program. There were 431 patients in the study, 106 who received cetyl myristoleate, 99 who received cetyl myristoleate, and glucosamine, sea cucumber, and hydrolyzed cartilage and 226 who received a placebo. Clinical assessment included radiological test and other studies. Results were 63% improvement for the cetyl myristoleate group, 87% for the cetyl myristoleate plus glucosamine group and 15% for the placebo group.

    In August of 2002, a double blind study was published in the Journal or Rheumatology. The study included sixty-four patients with chronic knee OA. Half of the patients received a cetyl myristoleate complex and half a placebo. Evaluations included physician assessment, knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI). The conclusion was that the CM group saw significant improvement, while the placebo group saw little to none. In fact in their conclusion they state that CM “may be an alternative to the use of nonsteroidal anti-inflammatory drugs for the treatment of OA”.

    Advanced Medical Systems & Design, Ltd. completed the last study I would like to mention in Oct 2001. It was not a double blind study, but the study included 1814 arthritis patients. The results showed that over 87% of the subjects had greater than 50% recovery and over 65% of those showed from 75% – 100% recovery following a sixteen day regimen. I know that this is not the most scientific study, but a study this large a study does suggest that there could be a positive benefit to the use of CM in the treatment of arthritis.

    Conclusion: There is mounting evidence that CM can be effective in the joint discomfort reliever of many forms of arthritis. While it is true that the evidence from these three studies can not be considered conclusive, it is a beginning. It should challenge you to think out side the box and consider that just because it did not come from a drug company does not mean that it will not work. With over 10,000 people a year dying from Nsaids, would it not be great to find a safer and more effective product, especially with the cost of prescription treatments for arthritis costing into the hundreds and good Cetyl Myristoleate products can be found for between $20 and $40.

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  3. Arrow Durfee Says:

    CMO is so important in the treatment of arthritis I will continue to provide more specific information as I can find it. This article clarifies some of the discrepancies on the different products. I still recommend Inflameze as listed in the first comment.
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    ADDITIONAL INFORMATION FOR HEALTH PROFESSIONALS

    CETYL MYRISTOLEATE, CMO™, AND COLLASTIN™

    MISINFORMATION

    There seems to be a lot of misinformation floating around regarding Cetyl Myristoleate and trademarked formulations which contain Cetyl Myristoleate. There are many companies who claim to sell products that contain Cetyl Myristoleate, when in fact, they contain no Cetyl Myristoleate at all, but instead contain myristic acid (not the same as myristoleic acid), which has no known effect on the arthritic process. There are also products on the market which state that it is necessary to break down the Cetyl Myristoleate molecule for maximum assimilation into the body. Using a 9-chain triglyceride process, the molecule is broken down into small units, primarily the two original naturally occurring molecules: cetyl alcohol and myristoleic acid. The problem with this, according to Dr. Chuck Cochran, is that your body lacks the enzymes necessary to put the molecule back together again. It will not function as Cetyl Myristoleate in the liver. In other words, when it gets into the liver, it must be as Cetyl Myristoleate – not the broken down components of Cetyl Myristoleate, which is vital for it to be effective. In Dr. Cochran’s book At Last Collastin™, he states “I’ve researched all of them (suppliers of cetyl myristoleate products) quite extensively and have personally used several of them, and after having three of the best cetyl myristoleate products chemically analyzed by independent laboratories, Collastin™ with its unique formulation, is the best cetyl myristoleate product available today.” Further confusion regarding cetyl myristoleate is even evident in well known publications such as, SECOND OPINION, which is published monthly and is highly regarded among medical practioners and nearly 100,000 “informed readers,” as you can see by the following article extracted from Vol. VI, No. 5 May 1996. In order to clear up the misunderstandings, we offer the information following this article. A correct understanding is vital BEFORE choosing a formulation such as Collastin™, or CMO™, for your own use, or that of your patients, clients, and friends.

    An article about Cetyl myristoleate.
    Second Opinion is Published monthly, is highly regarded among medical practitioners
    and nearly 100,000 informed readers. (Although Second Opinion is highly regarded among medical practitioners, as you can see by the article, much misinformation regarding cetyl myristoleate and CMO™ are evident, which greatly contributes to the widespread confusion. CMO™ is NOT Cetyl Myristoleate. Please refer to information below about CMO™, Cetyl Myristoleate, and Collastin™.)

    The following is Extracted From SECOND OPINION Vol. V1, No 5 May 1996

    “A New Miracle Cure for Arthritis

    Every few years there is a new miracle cure for arthritis. There was DMSO; a miracle cure from the Bahamas; acupuncture; cod-liver oil; chelation therapy; and many more. Most of these treatments help, but none of them have proved to be a cure. The drug industry has also been turning out one miracle cure after another, aspirin, tylenol, Ibuprofen, and all the little profens etc. But all these companies have managed to do is produce more side effects than the more naturalist doctors.

    But now we have a new star on the horizon that promises as much (or more) than the old sure cures. Again I’m skeptical, been through this so many times that I believe in the power of negative thinking, but it does indeed look promising. Harry Diehl, a 40-year-old employee of the U.S. Government, National Institute of Health reports: Four years ago I had arthritis so bad I could hardly walk and it was in my hands also. Diehl is 84 now and remarkably improved from treating himself with a compound I am still trying to learn to pronounce. It’s called cerasomal cis 9 cetyl myristoleate. The trade name is CMO, so that’s what we’ll call it.

    Diehl began testing CMO back in 1971 while still with the NIH and he continued to investigate it after he retired. The compound was isolated from Swiss albino mice and injected in laboratory rats. Then the (group of) rats injected with CMO and some rats who were not given CMO did not develop arthritis, but the unprotected ones all developed arthritis.

    CMO is also found in male beavers and sperm whale oil. There is now an oral preparation that seems to work as well as the injections. It is absorbed by the mid-intestine and then migrates to the joints where it attaches itself and alters the immune response to the pain and swelling…..

    When his rheumatologist told him he could no longer recommend cortisone to him, but only pain pills, Diehl went home, mixed a batch of CMO, and injected himself. His arthritis cleared quickly, as did his headaches and bronchitis. He thus made himself the first human guinea pig to be tested with CMO and just may make medical history. Yeah, here I go again; I’m really impressed with the reports I’m getting from my colleagues. This may be the cure we have been looking for. Even his doctor was so impressed with the results of his self treatment that he urged the Journal of Pharmaceutical Sciences to publish the report from Diehl, which they did.

    (One) study involved 48 subjects of both sexes ranging from 29 to 82. The CMO was given orally with capsules being taken morning and night. Only two subjects failed to show marked improvement or complete relief of all the symptoms. The two patients who did not respond were both found to have severe liver disease. It is thought that liver damage from prolonged cortisone treatment for arthritis may block the healing effect of CMO. Most patients had a 70% to 100% return of joint mobility and a 70% to 100% reduction in pain. The initial response time is two to seven days and maximum response time is from 7 to 21 days. I don’t own any part of the company and I have no claim on their sales, present and future, it’s going to cost you to find out (if it works for you), but I think it’s worth the investment.” END OF EXTRACT FROM ARTICLE.

    CETYL MYRISTOLEATE

    Cetyl Myristoleate is not CMO™, nor is it COLLASTIN™. Cetyl Myristoleate is the molecule that was developed by Harry W. Diehl, which started back in 1962 while he was working as a researcher and chemist at the National Institutes of Health in Bethesda, Maryland, assigned to the Institute of Arthritis, Metabolic, and Digestive Diseases.

    CETYLMYRISTOLEATE, is a medium-chained fatty acid (oil) originally discovered when it was observed that a certain strain of white mice were totally arthritis resistant. Cety-myristoleate is a waxy substance at room temperature, but a clear, light yellow oily material at body temperature. It can be laid upon an absorbent bed of powder and the end product compressed into a tablet, or it can be encapsulated into a two-piece hard shell capsule, or a gelatin softshell capsule. Cetyl myristoleate is a simple, natural nutrient…not a drug. And Cetyl myristoleate doesn’t cause any known side effects. Numerous, well-documented scientific studies have shown repeatedly the high efficacy of cety myristoleate in effectively treating patients afflicted with mild-to-severe cases of osteoarthritis, rheumatoid arthritis, and reactive psoriatic arthritis, and more recently, with many other auto-immune disorders. The results of these studies showed consistent, permanent relief from pain, inflammation, and marked deformation of nearly all interphalangeal & large joints.

    In 1962 Harry set up a laboratory in his own home, and for over two years he spent his weekends and evenings working by himself. His experiments to find a cure for arthritis started with mice that proved to be immune to arthritis. What he was looking for was already in the common mouse. After two years of chemical sleuthing and laboratory experimenting, he finally isolated the molecule that gave these mice their immunity to arthritis – cetyl myristoleate.

    His next step was to determine if a synthetic form was as effective as the cetyl myristoleate found in the mice. After creating the molecule from myristoleic acid and cetyl alcohol, he tested it on other laboratory animals. It proved to be just as effective.

    The next thing he did, was to approach the pharmaceutical industry with his wonderful discovery, but he was in for a rude awakening. He assumed that any one of these drug companies would jump at the opportunity to finish his research and develop a cure for arthritis. This was not the case. Because his discovery occurs in nature, the product itself could not be patented, only its use. Without a product patent, a drug company would not be able to control who manufactures it and with no control of the market, the profits would have to be shared. None of the companies he presented it to would even consider it. Harry ended up taking his marvelous healing nutrient and putting it on the shelf until 1991, when he himself developed osteoarthritis in his hands, knees, and feet. After going to his medical doctor for help and eventually being told that there was nothing else that could be done for him, did Harry go back to his own discovery of cetyl myristoleate and made up a batch to try on himself. Within 30 days his arthritis pain was totally gone!

    Even though Harry was a laboratory research scientist, his own experience motivated him to begin further studies. It was not until 1994 when he and a fellow chemist published his research in the Journal of Pharmaceutical Sciences that the health care industry became aware of it. Since cetyl myristoleate is an injectable oily substance that works best when it is injected at or near the site of the arthritic inflammation and has a very low bioavailability level in oral administration, it still took over two years to get to the point where material sources could be identified and processing methods developed to create a commercially-available product, hence, the trademarked formulations that contain Harry’s cetyl myristoleate – CMO™ and COLLASTIN™ .

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    CMO™

    CMO™ is not cetyl myristoleate! Cerasomal cis-9-cetylmyristoleate is CMO™. CMO™ is a proprietary trademark that identifies this particular product. Cerasomal cis-9-cetylmyristoleate is just a name coined by Dr. L. Sands to sound unique and to distinguish his CMO™ product from other similar products. It is in no way the only true cetyl myristoleate product available on the market, nor is it the most effective, contrary to what CMO™ Distributors will tell you.

    According to Dr. Chuck Cochran, Cerasomal cis-9-cetylmyristoleate, or CMO™ breaks the cetyl myristoleate down into a 9-chain triglyceride that the body lacks the proper enzymes to put back together, so that it reaches the liver as cetyl myristoleate. This is just one of the reasons why Dr. Cochran states that Collastin™ is much more effective, because it does reach the liver as cetyl myristoleate, which is critical. This might be one of the reasons why the instruction for using CMO™ states that additional supplements such as digestive enzymes can help and that they MUST contain lipase, amylase, and protease, but must not contain HCL (hydrochloric acid) or pancreatin, because these break down the CMO™ capsules too soon for proper absorption. The usage instructions also state that there are other supplements that will help the CMO™ be more effective such as, Bioflavanoids with Rutin, 1500mg -2000mg, Glucosamine Sulfate, Chondroitin Sulfate (and other cartilage products, because they assist in rebuilding worn cartilage in cases of osteo-arthritis, and Omega 3 supplements – fish oil or flaxseed oil.

    In clinical tests CMO™ has been consistently 10-20% effective. CMO™ sells for $95.00 for 60 capsules and $199.00 for 100 capsules that each contain 385mg of CMO™ (remember, CMO™ is not cetyl myristoleate).

    COLLASTIN™

    COLLASTIN™ is not cetyl myristoleate, nor is it CMO™. Collastin™ is a proprietary formulation that was formulated by one of the world’s largest encapsulators of pharmcopea grade nutritional products in the world. Collastin™ is a mixture of fatty acid esters. The principal fatty acid ester is cetyl myristoleate.

    Fatty acids are the individual components or building blocks of lipids (fats) or oils in the same way that amino acids are the building blocks of proteins. If we take a fatty acid and add an alcohol molecule to it, we create an ester of that fatty acid. The ester, in this case, is called cetyl myristoleate. It’s created by combining myristoleic acid, a fatty acid, with cetyl alcohol. If you take the cetyl myristoleate and combine it with a mixture of other fatty acid esters that work to complement each other, we create Collastin™ – the Rolls Royce of anti-aging products!

    How does Collastin™ work?

    The exact mechanisms of Collastin’s™ action are not fully understood. However, we can observe the results; and knowing the various etiologies or causes of certain diseases, we can make a hypothesis as to its mechanisms of action. First, Collastin™ functions as a surfactant, or super lubricant – a kind of WD-40 for the joints, as well as all of the other body tissues. A surfactant not only has a dissolving or thinning action, it also makes other nutrients easier to absorb. Because of Collastin’s™ lubricating abilities, it makes the joints move more freely; it makes muscles glide more smoothly over other muscles, bursas, and bones; and at the same time, it softens these tissues making them more pliable. It also makes blood vessels more resilient, which allows them to expand and contract with the increase and decrease of blood volumes as the heart pumps. Hardening of the arteries, which contributes to heart disease – one of the major causes of death in our country – can also contribute to high blood pressure due to inelasticity of the arterial walls. Collastin™ not only lubricates the muscles, tendons, blood vessels, and joints, but every part of your entire body!

    Secondly, it functions as an immune system modulator and possible stimulator. This is no doubt, on of the most exciting roles of Collastin™. As an immuno-modulator, it has been found to be effective in treating auto-immune disorders like rheumatoid arthritis and systematic lupus erythematosus. And last, it functions like omega-3 and omega-6 fatty acids in that it mediates inflammatory process. This last mechanism is probably the reason that we are seeing such far-reaching effects.

    Cetyl myristoleate is presently being used to treat many inflammatory conditions, including Crohn’s disease; irritable bowel syndrome; chronic bronchitis and emphysema; bursitis; tendonitis; rheumatoid and osteoarthritis; psoriasis and psoriatic arthritis; muscle tension headaches; and prostatitis. The one symptom common to most disease process at one state or another is inflammation. Inflammation is a normal response by the body to injury, and functions as part of the healing process. It becomes a problem, however, when it’s uncontrolled and starts to produce more tissue damage.

    To really understand how Collastin™ can work on so many different conditions, you need to know a little bit about prostaglandins and leukotrienes. Prostaglandins are a large group of biologically-active, unsaturated fatty acids that act almost like hormones, but unlike hormones their effects are local. In other words, they don’t travel in the blood and effect organs or tissues in other parts of the body. They are modulators of the tissues in which they are formed. Prostaglandins are not only important in regulation of inflammation, pain, and swelling, they also help to regulate blood pressure, heart function, platelet aggregation (clotting factors), gastrointestinal function and activity, pancreatic hormone function, and nerve transmission. So, if we had something that regulated these prostaglandins, you could see how far-reaching such a product might be.

    All these prostaglandins fall into three categories depending on how the carbon atoms are hooked together, specifically the number of double bonds. Series one and two come from the omega-6 fatty acids and series three comes from the omega-3 fatty acids. Series one and three prostaglandins are the favorable, or good prostaglandins; and prostaglandins in the second series are considered the unfavorable ones. For instance, prostaglandins of the second series cause increased inflammation, induce constriction of blood vessels, and promote platelet stickiness – factors that can increase the risk of heart disease and stroke. And as inflammation increases within damaged tissues, swelling and pain increase along with the chance of further damage by cutting off normal blood supply. In contrast, prostaglandins of the first and third series reduce inflammation, prevent the platelets from sticking together, and improve blood flow. By adding Collastin™ to your daily diet, you can manipulate prostaglandin metabolism, making sure that the good prostaglandins are in abundance and the bad prostaglandins are kept at a minimum. The big difference in Collastin™ – when compared to any other similar products – is the speed at which results are seen and the thoroughness of its activity. Patients who had been experiencing symptoms for years and had tried many, many different therapies, found total relief within a few days to a couple of weeks.

    Leukotrienes are like prostaglandins in that they are chemical mediators of inflammation. Leukotrienes cause smooth muscle contraction in blood vessels and bronchial airways, and they also cause increased permeability in the blood vessels which results in edema or swelling of tissues. These substances also play an important role in asthma because of their ability to stimulate contraction of the smooth muscles that line the airways going into the lungs. Collastin™ may function as a leukotriene inhibitor. Many patients with airways that have been obstructed due to either inflammation or muscle contraction are now able to breathe better than they have in years!

    One possible explanation of Collastin’s™ ability to mediate an immune system that is attacking its own tissues and causing an auto-immune disease, is the inhibition of leukotriene B4 production. Leukotriene B4 is a compound that has potent chemotactic activity for certain phagocytic cells. These phagocytic cells normally ingest and destroy substances such as bacteria, protozoa, cells and cellular debris, but in auto-immune disorders they start to attack and ingest healthy tissues. In other words, Leukotriene B4 sends out a message to these phagocytic cells which affects their ability to differentiate the “good guys” from the “bad guys,” telling them to “come here quickly.” Suddenly, in one location, we have a whole bunch of Pac-Man-like activity eating up healthy tissues! Leukotrienes C4, D4, and E4, are responsible for producing many of the sympotms related to allergic reactions. Inhibiting leukotriene production may be one of the explanations for Collastins™ far-reaching results.

    AMOUNT OF CETYL MYRISTOLEATE IS CRUCIAL TO EFFECTIVENESS OF PRODUCT

    According to Dr. Cochran, “the amount of cetyl myristoleate is crucial to the success of the product.” COLLASTIN™ is comprised of 40% Cetyl myristoleate, containing 12-14 grams of cetyl myristoleate in a one month supply, added to other fatty acid esters, and making it the most potent form of cetyl myristoleate available (128 mg. per soft gel capsule). Our Saturation formula by itself is 60 – 70% effective, but when combined with our Maintenance Support formula, it is up to 88% effective!

    Increasing effectiveness of Collastin™

    As fantastic as Collastin™ is, its effectiveness can be improved by another 10 to 20 percent by adding a few additional natural ingredients, which can be found in our Maintenance Support formulation.

    In nature, we observe that nothing works or stands alone. Collastin™ itself has a group of fatty acid esters working with the cetyl myristoleate to increase its effectiveness. There always seems to be a collaboration, or supporting complementary action, which makes things happen. This synergistic interaction produces a total effect that is greater than the sum of the individual effects.

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    Glucosamine Hydrochloride

    Next to Collastin™, glucosamine has relieved the symptoms of osteoarthritis more than any other one nutrient. Glucosamine is manufactured by the body and is primarily to help form the cushioning components of joint fluids and surounding tissues. It thickens synovial fluid, making it more elastic; repairs the cartilage in damaged arthritic joints; and creates more support for joints, including the vertebrae. Besides helping to form the cartilage, tendons, ligaments, and snyovial fluid in the joint, it also plays a role in the formation of nails, skin, eyes, bones, and heart valves. And, finally, it’s involved in the mucous secretions of the digestive, respiratory, and urinary tracts.

    As we age, we lose the ability to manufacture glucosamine, which results in degeneration of the structures within the joints. Since we don’t get a significant amount in our diets, we need to supplement with some form of glucosamine. Available sources of glucosamine are derived from chitin, the exoskeleton of shrimp, lobsters, and crabs. Presently, it’s commercially sold in three forms: 1) glucosamine sulfate (GS); 2) N-acetyl-glucosamine (NAG); 3) glucosamine hydrochloride (GHCL). The N-acetyl-glucosamine has been found to be not as effective in treating joint conditions, and actually very little, if any, ends up in the joints. After reading the research comparing glucosamine sulfate to the glucosamine hydrochloride, Dr. Cochran started recommending the hydrochloride form, because it’s found to be just as effective, and it’s less expensive.

    There will be many health care providers who claim that sulfate form of glucosamine is more effective than the hydrochloride form, but the information found by Dr. Cochran are pretty convincing. First of all, most of the studies done from 1980 to 1994 were with the sulfate form because it was made available by the Italian pharmaceutical company which had a proprietary position or patent on the sulfate. So, it was to their advantage to make the sulfate form available for clinical studies. However, in studies performed as early as 1971, comparing the effects of glucosamine sulfate, glucosamine iodide, and glucosamine hydrochloride, it was found that glucosamine hydrochloride had the strongest effect.

    The reason for its stronger effect is that it’s much more pure. Actually, glucosamine sulfate is made from glucosamine hydrochloride by adding either sodium or potassium sulfate. Adding these additional compounds increases the cost by another 50percent. All of the glucosamine sulfate imported into the United States is only 80 percent pure, with the remaining 20 percent being sodium or potassium chloride. This is done because the glucosamine sulfate is very unstable and tends to decompose, turn brown, and lose its effectiveness. Glucosamine hydrochloride, on the other hand, is very stable and is 99 percent pure. In this unmixed form, it delivers 83 percent of the glucosamine to the joints. Glucosamine sulfate mixed with other salts distributes only 62 percent of the glucosamine to the joints. Put another way, you would have to take 1995 milligrams of glucosamine sulfate to equal the effects of 1500 milligrams of glucosamine hydrochloride! This decreases your cost even further.

    You may also hear that the sulfer in the glucosamine sulfate is necessary for the construction of the cartilage matrix. The original researchers of glucosamine sulfate found, however, that the results obtained in treating osteoarthritis were due to the glucosamine and not to the sulfate. They discovered that the sulfate, chloride, and iodide salts are passed from the body as waste. And the sulfer used to construct these joint structures actually comes from existing proteins present in the cartilage.

    Sulfer is, however, critical in reconstructing connective and joint tissue and can be increased by consuming more sulfer-containing foods including garlic, onions, eggs, and asparagus, or by taking a supplement like MSM.

    Another interesting point to consider is what really happens during the digestion of glucosamine sulfate. Your stomach contains hydrochloric acid which is necessary for the digestion of food. When the glucosamine sulfate enters the stomach, the sulfate portion is split off and the hydrochloride is attached to the glucosamine creating glucosamine hydrochloride! The sulfate molecule is essentially lost due to its very low concentrations, compared to the large amount of hydrochloric acid present in you stomach. If your body is going to turn it into glucosamine hydrochloride, why not take it in that form in the first place and eliminate all the unnecessary salt that you probably don’t need anyway.

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    Enzyrest™

    Enzyrest™ is a special blend of phytonutrients that are extracted from a specific group of botanicals. We were so impressed with these amazing new plant extracts that we went back to the drawing board and totally reformulated one of our best selling products. We are now confident that when it comes to providing relief from joint and muscle discomfort, our all-natural maintenance support formula is in a league by itself.

    Enzyrest™(enzyme-arresting) is a complex of plant extracts known as phytonutrients that have been found to inhibit the COX-2 enzyme along with other enzymes. These enzymes are implicated in the degenerative, inflammatory process that damages and ages tissues. All of this is accomplished with NO adverse side effects.

    Digestive Enzymes

    It is ALWAYS highly recommended to supplement your diet with digestive enzymes! This cannot be stressed enough. You need to gain a thorough understanding of the digestive process that takes place in the stomach once food has been ingested. Many of the conditions we see today are directly related to the body’s inability to completely digest food. Undigested food particles end up in the blood stream in an unusable form. The body sees these food particles as foreign invaders and kicks in with the immune response, which happens every time food is eaten! The condition is called digestive leukocytosis and can be diagnosed by evaluating the number of white blood cells in the blood, before and after one eats. No wonder many people have immune systems that are extremely overworked and very tired.

    NOTE: Our Maintenance Support Formulation DOES NOT include Digestive Enzymes, however, we do offer one of the best and most complete formulations on the market today that also includes “friendly” bacteria.

    Our Enzyme Formulation
    NOTE: Much of the above information regarding Collastin™ and the additional beneficial nutrients can be found in Dr. Cochran’s book At Last Collastin™

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    STUDIES

    There have been two clinical studies completed recently. One of them involved 431 patients with various forms of arthritis. The results were remarkable.Very significant improvement was observed in 64 percent of the individuals using the fatty acid esters found in COLLASTIN™; and 87 percent showed improvement by combining these esters with other important nurtients that are mentioned above.

    In another study comprised of 48 patients with osteoarthitis, rheumatoid arthritis, and reactive psoriatic arthritis, only two of these individuals failed to respond. These two were found to have liver disease, one from alchol abuse ant the other from extensive steroid use. Liver disfunction has been shown to interfere with the action of Collastin™ and reduce its effectiveness. In his research, Harry Diehl found that the liver acts as a storage center for cetyl myristoleate, and adequate liver function appears to be necessary for effectiveness.

    Mild to Moderately Severe Osteoarthritis & Reactive Psoriatic Arthritis
    In group #1, eleven subjects presenting with mild to moderately severe osteoarthritis and one with reactive psoriatic arthritis were supplied with 16 capsules, two 75mg capsules to be taken each morning and evening for four days. Nine reported about 20% to 30% improvement in articulation and inflammation and about 40% to 50% relief of arthritic pain in 36 hours. In these nine subjects, improvement continued rapidly for the next 60 hours, reaching a 70% to 80% overall improvement by the end of the four days. Two of the three latter subjects continued to improve over the following week despite the fact that they were no longer taking the capsules. However, about half of this group experienced the return of some mild arthritic symptoms after about three to five weeks. (Although not included as part of this study, all subjects in this group were treated again and their symptoms have not returned). The patient with reactive psoriatic arthritis also experienced an almost complete reversal of his associated very severe psoriatic skin condition affecting about 20% of his total skin.

    Severe to Crippling Rheumatoid Arthritis
    In group #2, nine subjects presenting with severe to crippling rheumatoid arthritis were supplied with 50 capsules to be taken in 2 series, two 75mg capsules each morning and evening for seven days, with a seven-day interval before repeating the same dosage for 5 ½ more days. Four of these subjects were unable to walk and were accustomed to being transported by wheelchairs. One, her femur being fused at the hip, was unable to achieve a sitting position for wheelchair transport. She could, however, move about slowly on crutches as long as she was accompanied by someone to aid her maintaining her balance. Otherwise she could only stand or lie down. The remaining four could move about with canes or walkers. All nine subjects presented with pain, inflammation, and large joints. Five presented with limited lumbar flexion and pain in the vertical column. All had difficulty grasping and manipulating common objects.

    Within three days of treatment, six subjects in the group reported a 30% to 50% decrease in pain and 20% to 30% increase in joint mobility, and three subjects reported little change. Within seven days, five subjects reported a 70% to 90% decrease in pain and a 70% to 80% increase in joint mobility. Three subjects reported to be totally free of pain with almost complete return of joint mobility and marked improvement in joint deformation. One patient reported no perceptible change.

    On the fourteenth day, at the end of the one week interval without treatment, six subjects reported minor continuing improvement; two reported maintaining their improved status, and one continued to show no improvement. Treatment was resumed on the fifteenth day for 5 ½ more days.

    By the end of the treatment period all but two subjects reported to be 90% free of pain with return of 70% to 100% mobility. The fused hip joint remained fused, but with the return of over 70% mobility in the other joints the subject felt hip surgery now to be worth consideration. The one non-responsive subject proved to have cirrhosis of the liver, which may have been the reason of her inability to respond to treatment. Further investigation is necessary to determine the role of liver function in this Protocol.

    Mild to Moderately Severe Rheumatic Arthritis
    In group# 3, fourteen subjects presenting with mild to moderately severe rheumatoid arthritis were supplied with 24 capsules, two 75mg capsules to be taken each morning and evening for six days. After three days of treatment, eleven reported about 20% to 30% improvement in articulation and inflammation, and about 40% to 50% relief of arthritic pain. In these eleven subjects improvement continued rapidly over the next four days, approaching the 80% to 100% level. The remaining three subjects reported similar improvements by the end of the fourth day, with an overall improvement of 70% to 80% after seven days.

    Most of the subjects continued to report minor additional improvement for one week or more even though they were no longer under treatment. However, six in this group began to experience the return of some mild arthritic symptoms after about three to four weeks. (Although not included in this study, all of the subjects in this group were treated again and their level of improvement has subsequently stabilized).

    Severe to Crippling Osteoarthritis
    In group#4, fourteen subjects presenting with severe to crippling osteoarthritis were supplied with 50 capsules to be taken in two series, two 75mg capsules each morning and evening for seven days, with a seven-day interval before repeating the same dosage for 5 ½ more days. Three of these subjects were unable to walk and were accustomed to being transported by wheelchairs. The other eleven could move about with crutches, walkers, or canes. All presented with pain, inflammation, and marked deformation of nearly all interphalangeal and large joints. Four presented with limited lumbar flexion and pain in the vertical column. Ten had difficulty grasping and manipulating common objects.

    After four days of treatment, ten in this group reported 30% to 50% improvement in articulation and inflammation and about 40% to 60% relief of arthritic pain. In these ten subjects improvement continued rapidly over the next three days, reaching 80% to 100% by the end of seven days. One reported no perceptible change.

    On the fourteenth day, at the end of the one week interval without treatment, four reported maintaining their improved status, and one continued to show no improvement. Treatment was resumed on the fifteenth day for 5 ½ more days.

    By the end of the treatment period, eleven subjects reported 80% to 100% relief of pain with a return of 80% to 100% mobility. Two subjects reported 70% to 80% return of articular mobility with a 70% to 90% reduction in arthritic pain. The one non-responsive subject proved to have previous liver damage as a result of sports related steroid abuse. Further studies are necessary to determine the role of liver function in this Protocol.

    Summary
    The results of this study lead to several conclusions regarding its five principal objectives:

    Optimum dosage levels appear to be equal for all three types of arthritis investigated:
    osteoarthritis, rheumatoid arthritis, and reactive psoriatic arthritis. This evidence by the gradual return of minor arthritis symptoms in several of those treated with only 16 or 24 capsules and no regression in those treated with 50 capsules in two series separated by one week without treatment.

    Dosage level requirements appear to be equal irrespective of the severity of the subject’s condition. Initial response time for minor improvement appears to vary from two to seven days irrespective of the severity of the subject’s condition.

    The time for maximum attainable response appears to vary from seven to twenty-one days, resulting in 70% to 100% overall improvement. (Apart from this study, three of the most severely afflicted subjects were treated again after a five-week interval, resulting in an additional 10% to 20% overall improvement.)

    The two non-responding subjects both proved to have suffered previous damage to the liver from steroid or alcohol abuse, indicating that impaired liver function may preclude success with this Protocol.

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    REFERENCES

    Diehl, H. and May, E.L., Cetyl Myristoleate Isolated from Swiss Albino Mice: An Apparent Protective Agent Against Adjuvant Arthritis in Rats, Journal of Pharmaceutical Science, Vol. 83, March 1994.
    United States Patent #4049824, September 20, 1977, Cetyl Myristoleate.
    NutriPlus ’97 SDI Systems, Inc., Dallas, Texas
    CMO™: CMO™ is a copyrighted name of Cerasomal-Cis-9-Cetyl Myristoleate, which this manufacturer claims is an analog of Cetyl Myristoleate.
    Denman, A.M., et al., Joint Complaints and Food Allergic Disorders. Ann. Allergy, 1983.
    De Vos, M., Articular Diseases and the Gut; Evidence for a Strong Relationship Between Spondyloarthropathy and Inflammation of the Gut in Man. ACTA Clinica Belgica 45(1) 1990.
    Golding, D.N., Is There an Allergic Synovitis?, Journal of the Royal Society of Medicine, May 1990.
    Kremer, J.M., Effects of Manipulation of Dietary Fatty Acids on Clinical Manifestations of Rheumatoid Arthritis, Lancet 1985.
    Panush, T.S., Food Induced Arthritis: Clinical and Serological Studies. Journal of Rheumatology 17(3) 1990.
    Ammon, H.P. et al., Mechanism of Anti-inflammatory Actions of Curcumine and Boswellic Acids. Ethnopharmacol. 38(2-3) 1993.
    Safayi, H., et al., Boswellic Acids: Novel, Specific, Nonredox Inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3) 1992.
    Ammon, H.P., et al., Inhibition of Leuotriene B4 Formation in Rat Peritoneal Neutrophils by an Ethanolic Extract of the Gum Resin Exudate of Boswellin Serrata. Planta. Med. 57(3) 1991.
    Setnikar, I., et al., Pharmacokinetics of Glucosamine in Man. Arzeim Forsch 43(10), 1993.
    Setnikar, I., et al., Pharmacokinetics of Glucosamine in the Dog and Man. Arzneim Forsch 36(4), 1986.
    Crolle, G. and D’este, E., Glucosamine Sulfate for the Management of Arthrosis: A Controlled Clinical Investigation. Curr. Med. Res. Opin. 7, 1980.
    Drovanti, A. et al., Therapeutic Activity of Glucosamine Sulfate in Osteoarthrosis: A Placebo-controlled Double-blind Investigation. Clinical Therapeutics, 3(4), 1980.
    Pujalte, J.M. et al., Double-blind Clinical Evaluation of Oral Glucosamine Sulfate in the Basic Treatment of Osteoarthrosis. Curr. Med. Res. Opin. 7(2), 1980.
    Setnikar, I. Pacini, A., and Revel, L., Antarthritic Effects of Glucosamine Sulfate Studies in Animal Models. Arzneim Forsch 41, 1991.
    Tapadinhas, M.J., et al., Oral Glucosamine Sulfate in the Management of Arthrosis: Report on a Multi-center Open Investigation in Portugal. Pharmatherpeutica, 3, 1982.
    Vaz, A.L., Double-blind Clinical Evaluation of the Relative Efficacy of Ibuprofen and Glucosamine Sulfate in the Management of Osteoarthritis of the Knee in Out-patients. Curr. Med. Res. Opin. 8, 1982.
    Pasquier, C., et a;., Manganese-containing Superoxide-dismutase Deficiency in Polymorphonuclear Leukocytes of Adults With Rheumatoid Arthritis. Inflammation 8 1984.
    Murray, M., Encycolopedia of Nutritional Supplements. Prima Publishing, Rockin, CA 1996.
    Mourao, P. A., et al., Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate From Echinoderm. Sulfated Fucose branches on the Polysaccharide Account for its Highe Anticoagulant Action. Jour. Biol. Chem. 271(39) 1996.
    Trotter, J.A., et al., Atiparin: A Glycoprotein From Sea Cucumber Dermis that Aggregates Collagen Fibrils. Matris. Biol. 15(2) 1996.
    Riberio, A.C. et al., A Sulfated Alpha-L-fucan From Sea Cucumber. Carbohydr. Res. 255 1994.
    Vieira, R.P. et al., Extensive Heterogeneity of Proteoglycans Bearing Fucose-branched Chondroitin Sulfate Extracted From the Connective Tissue of Sea Cucumber. Biochemistry 32(9) 1993.
    Boosalis, M.G., et al., Impaired Handling of Orally Administered Zinc in Pancreatic Insufficiency. Amer. Jour. Clin. Nut. 37 1983.
    Eby, G.A., et al., Reduction in the Duration of Common Colds by Zinc Gluconate Lozenges in a Double-blind Study. Antimicrobial Agents and Chemootherapy 25 1984.
    Fahim, M., et al., Zinc Treatment for the Reduction of Hyperplasia of the Prostate. Federation Proceedings 35 1976.
    Michaelson, G., et al., Serum Zinc and Retinol Binding-protein in Acne. Brit. Jour, of Dermatology. 96 1977.
    Pandley, S.P., et al., Zinc in Rheumatoid Arthritis. Ind. Jour. of Med. Research 81 1985.
    Ripa, S., Zinc and Immune Function. Minerva-Med. 86 1995.
    Russel, R.M., et al., Zinc and the Special Senses. Annals of Internal Medicine 99 1983.
    Sandstead, H.H. et al., Zinc Nutriture in the Elderly in Relation to Taste Acuity, Immune Response, and Wound Healing. Amer. Jour. Clin. Nut. 36 1982.
    Simkin, P.A. Treatment of Rheumatoid Arthritis With Oral Zinc Sulphate. Agents and Actions (Supplement) 1981.
    Whitehouse, M.W., et al., Zinc Monoglycerolate: A Slow-release Source of Zinc With Anti-arthritis Activity in Rats.Agents and Actions 31 1990.

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    Send Questions to :Timeless Endeavors , or call: 1-623-374-9306 or 1-877-497-2454

  4. Arrow Durfee Says:

    This is the link for comment #3. I forgot to put it in.
    http://www.simplecom.net/timeless/profess.htm

  5. sherrie Says:

    All of this is very interesting. I did not hear any mention of pH balance which is the key to curing arthritis. It can also explain why many of these therapies are not working. Visit http://beam.to/relief to learn more about pH balance.

  6. Arrow Durfee Says:

    I am happy to report that after advising a friend of mine who has suffered with arthritis in her hands and wrists for a very long time decided to try the cmo. After about 2 months of use she has reported significant improvement. She is in her late 70′s and has really had pain for a long time.

  7. Leigh Says:

    Those are some scary stats about arthritis, especially the story about the court reporter; I’m a writer/reporter myself and experience some minor joint pain–I’ve found that stretching exercises help, as does a cream called Joint Medic.

  8. Linda Harris Says:

    I am 61 years old with very bad knees , hands and feet I have no insurance. I have read your article and would greatly like to try the formula of CMO, fish oil, glucosamine sulfate , vitamin E and the enzyme liapase. You mentioned dosages (grams and timetables) but not where I could get CMO or how much of it I should take with the above formula. I would appreciate any help you can give me.

  9. Cetylmyristoleate Says:

    Dr.Harry W. Diehl was the discoverer of Cetyl Myristoleate. Best known for his Award winning research of CM8 and its great effectiveness in the treatment of osteo-arthritis symptoms.

  10. cheapthrills Says:

    I found a great article on candida albicans and weight loss at http://hubpages.com/hub/CandidaAlbicansAndWeightLoss. Although the article deals with the weight loss aspects of candida albicans overgrowth, or yeast infections, there is far more comprehensive information on how the problem starts and what can be done to bring your body flora back in balance.

  11. Arrow Durfee Says:

    In the first comment listed here I gave contact info for purchasing CMO. This company no longer supplies CMO and boy did I give them a piece of my mind!

    Since I stockpiled Inflameze when I heard that they were no longer going to produce it I have not tried any other products, so I can’t make a recommendation. Here is a souce for a variety of cmo products
    http://www.iherb.com/Search?kw=cmo+#p=1&sr=0

    This company offers a refund if it does not work.. I paid about 79 dollars for my first bottle of cmo, till the price dropped due to manufacturing changes… it was the best $79 I ever spent.
    http://www.bestcmo.com/compare.html

  12. Arrow Durfee Says:

    For acute inflammation of arthritis I have found the 300mg of CMO 2 times a day is most effective.

    As time goes by and the condition improved you can reduce the dosage as tolerated.