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Cucurmin for Alzheimers?

9th January 2007 by Arrow Durfee Posted in Uncategorized

Curcumin has potent anti-amyloidogenic effects for Alzheimer’s beta-amyloid fibrils in vitro

Ono K, Hasegawa K, Naiki H, Yamada M. J Neurosci Res. 2004 Mar 15;75(6):742-50.

Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Inhibition of the accumulation of amyloid beta-peptide (Abeta) and the formation of beta-amyloid fibrils (fAbeta) from Abeta, as well as the destabilization of preformed fAbeta in the central nervous system, would be attractive therapeutic targets for the treatment of Alzheimer’s disease (AD). We reported previously that nordihydroguaiaretic acid (NDGA) and wine-related polyphenols inhibit fAbeta formation from Abeta(1-40) and Abeta(1-42) and destabilize preformed fAbeta(1-40) and fAbeta(1-42) dose-dependently in vitro. Using fluorescence spectroscopic analysis with thioflavin T and electron microscopic studies, we examined the effects of curcumin (Cur) and rosmarinic acid (RA) on the formation, extension, and destabilization of fAbeta(1-40) and fAbeta(1-42) at pH 7.5 at 37 degrees C in vitro. We next compared the anti-amyloidogenic activities of Cur and RA with NDGA. Cur and RA dose-dependently inhibited fAbeta formation from Abeta(1-40) and Abeta(1-42), as well as their extension. In addition, they dose-dependently destabilized preformed fAbetas. The overall activities of Curcumin, RA, and NDGA were similar. The effective concentrations (EC(50)) of Curcumin, RA, and NDGA for the formation, extension, and destabilization of fAbetas were in the order of 0.1-1 microM. Although the mechanism by which Curcumin and RA inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro remains unclear, they could be a key molecule for the development of therapeutics for AD.

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6 Responses to “Cucurmin for Alzheimers?”

  1. RTust Says:

    Just a note to say I’ve been reading about curcumin also, and all the positive effects it is having on inflammatory conditions! I’ve been taking it to assist in getting clear from psoriasis! (along with several other non-medical choices!)
    Here is a link that talks about Alzheimers disease and curcumin (turmeric)

  2. Arrow Durfee Says:

    Thanks for the lead to this article! There is a condition similar to Alzheimers that involves accumulation of amyloid plaque through out the body and not in the brain, mysteriously so. I have seen several people die of this disease that is never mentioned by the media. It seems to progress faster than the ususal course of alzheimers. Plaque can be found in the stomach, intestines, liver etc. Perhaps cucurmin would help this also.

  3. SaraAtTheSea Says:

    Wow. Guess I should by stock in a cucurmin company! I’ve been using it on and off for about a year but I didn’t realize that it could do so many things. Guess I will have to get more consistent with the program.

  4. Alzheimers disease news Says:

    Data from the study, the largest of its kind, contradicts some previous studies that found that ibuprofen might exceed others in its class when it comes to preventing this type of dementia. Besides ibuprofen, other types of NSAIDs include naproxen and aspirin.

    But the bottom line, the study authors said, is that the findings don’t support the use of NSAIDs to prevent or treat Alzheimer’s, at least not yet anyway.

  5. Peter Yexley Says:

    An inspiration to everyone who is affected by Alzheimer’s Disease.

    Carers and patients need to be aware of anything that can improve their quality of life.

  6. Arrow Durfee Says:

    Tumeric supplements for best effect should be taken with coconut oil to facilitate best absorption. Coconut oil in and of itself is showing great promise for Alzheimer’s patients. Do a google search on Alzheimer’s and coconut oil and you will find articles about one physicians experience in treating her husband with coconut oil for his Alzheimer’s disease.